Abstract Search

Background: The Clock/Bmal1 transcription factor heterodimer regulates the circadian activities of many biological systems, including the hypothalamic-pituitary-adrenal (HPA) axis, by trans-activating or trans-repressing downstream target genes. 1,25 Dihydroxy Vitamin D (Vitamin D), a sterol hormone that is activated by exposure to sunlight, plays a fundamental role in maintaining calcium and phosphorus homeostasis. Recent evidence suggests that the nuclear vi...

0 shares

hrp0089lb-p4 | Late Breaking P1 | ESPE2018

An Updated Evolutionary Study in Glucocorticoid Receptors; Insights from a Comprehensive Phylogenetic, SNP’s and Mutation’s Analysis of the Nuclear Receptors Family: An Updated Evolutionary Study in Glucocorticoid Receptors; Insights from a Comprehensive Phylogenetic, SNP’s and Mutation’s Analysis of the Nuclear Receptors Family

Papageorgiou Louis , Papakonstantinou Eleni , Salis Constantinos , Raftopoulou Sofia , Mitsis Thanasis , Nicolaides Nicolas , Hagidimitriou Marianna , Eliopoulos Elias , Charmandari Evangelia , Chrousos George , Vlachakis Dimitrios

Background: Protein subfamilies within the Nuclear receptor (NR) family share common domain architecture. These closely related receptors and their cognate ligand compounds play a key role in homeostasis, reproduction, growth, and development. Despite their biological significance, their evolution and diversification remains to be elucidated. SNPs and mutations are characterized by the permanent alteration of the nucleotide sequence in the genome of an organism. These alterati...

0 shares

ePoster

ESPE Abstracts

Vitamin D may facilitate Clock/Bmal1-DNA interactions in a Vitamin D receptor-independent fashion

BiosciAbstracts